Breast Cancer Increases: sign of increasing testosterone

James Howard (phis@sprynet.com)
Sun, 17 Nov 1996 19:28:12 GMT

Increasing breast cancer in the U.S. is another, current sign of increasing
testosterone. I sent the following to my local newspaper. It is my response
to a "Newsday" report by Ridgely Ochs, Nov. 6, that was in my newspaper. I
thought this newsgroup might find it interesting. It is about a theory of
breast cancer.

"Study links bone density, breast cancer," page D3, Nov. 6, reported that
postmenopausal women "who had the higest bone-mineral density were at 2.0 to 2.5
times the risk of breast cancer compared with women with the lowest
bone-mineral." While the investigators who did the study think estrogen is
directly involved, they suggest "It could be other hormones." I certainly think
other hormones are involved. May 16, 1993, I suggested in the ...News, page 2D,
that I think testosterone is rising in this society; March 7, €94, I suggested
increases in testosterone and low levels of the hormone, DHEA, may cause breast
cancer. This is why I think breast cancer is rising so rapidly, and this report
of a link between strong bones and breast cancer suppots my idea that an
increase in testosterone is definitely linked to the rise in breast cancer.

When estrogen is produced by the ovaries, testosterone is also produced. While
loss of estrogen is thought to be the cause of osteoporosis, a strong case can
be made that it is really loss of testosterone. When female monkeys are given
the strong androgen, testosterone, compared to weak androgens, bone-mineral
density increases. "We conclude that in the young [female] cynomolgus monkey,
long-term androgenic treatment significantly improves some of the mechanical
properties of both cortical and trabecular bones, increases bone density, and
the stronger the androgen, the more pronounced is the effect" (Bone 1995; 17:
265). In other research, when testosterone is used with estrogen, bone mineral
density is increased. "We concluded that in postmenopausal women, treatment
with combined estradiol and testosterone implants was more effective in
increasing bone mineral density in the hip and lumbar spine than estradiol
implants alone." (Maturitas 1995; 21: 227) Women who produce more testosterone
have increased bone mineral density. While my idea that testosterone is rising
should mean less osteoporosis, a medline search of the literature clearly shows
that osteoporosis is actually increasing. Increasing life-span is clearly
overwhelming any benefits of increased testosterone in women. The key is that
osteoporosis in women is "six-fold that of men;" the increased life-span of
women cannot account for this large difference. Men exhibit less osteoporosis,
I suggest, because they produce more testosterone.

I sent my hypothesis of high testosterone and low DHEA in breast cancer to the
Journal of the American Medical Association, Feb 4, €94. It was rejected.
Later, in 1994, two reports connected high testosterone and low DHEA
in breast cancer in women: "Abnormal Production of Androgens in Women with
Breast Cancer," Anticancer Res. 1994, 14: 2113 and "Hormonal Profiles in Women
with Breast Cancer," Obstet. Gynecol. Clin. North Am. 1994; 21: 751.

One known risk factor in breast cancer in women is early menstruation (puberty).
This early onset of puberty may also be attributed to the increase in
testosterone. My work suggests testosterone is rising in the U.S. I think
this increase in testosterone is the cause of the "secular trend," i.e., the
increase in size, and earlier puberty, in children. This is why breast cancer
may be increasing. I suggest the connection of increased bone density and
increased breast cancer in women is due to this increase in testosterone.
James Howard